Middle East Journal of Rehabilitation and Health Middle East Journal of Rehabilitation and Health Middle East J Rehabil Health http://www.jrehabilhealth.com 2423-4451 10.5812/mejrh. en jalali 2017 5 27 gregorian 2017 5 27 4 1
en 10.17795/mejrh-41821 Ozone Improves Pain, Function and Quality of Life in Patients with Knee Osteoarthritis: A Prospective Quasi-Experimental Before-After Study Ozone Improves Pain, Function and Quality of Life in Patients with Knee Osteoarthritis: A Prospective Quasi-Experimental Before-After Study research-article research-article Conclusions

Ozone is a safe medical treatment that can improve significantly pain relief, stiffness, and function in patients with knee osteoarthritis. The study shows a good level of evidence as well as a good grade of recommendation that allows us to consider Ozone as a conservative therapeutic option in the treatment of osteoarthritis of the knee.

Background

The study was conducted to: 1) demonstrate the effectiveness of a treatment protocol with Ozone therapy in pain, function, and quality of life in patients with knee osteoarthritis; and 2) apply Ozone as a conservative treatment option with a demonstrable level of scientific evidence.

Methods

This prospective quasi-experimental before-after study was conducted on 119 patients with knee osteoarthritis, having Kellgren-Lawrence grade 2 or more, who were referred to hospital of Santa Cristina’s University, from January 2012 to April 2016. The protocol consisted of an intra-articular infiltration of a medical mixture of Oxygen-Ozone (95% - 5%) 20mL, at a 20ug / mL concentration, during a total number of 4 sessions (once per week). Pain and quality of life were measured by visual analogical scale (VAS) and Western Ontarion and Mc Master Universities Index for osteoarthritis (WOMAC) at the beginning and end of the treatment.

Results

The mean age of participants was 66.29 years. The sample was composed of 70.5% Women (n = 84) and 29.5% men (n = 35). The severity of OA according to Kellgren-Lawrence scale was 2.94°. Post-puncture erythema was 8.4% (n = 10). Pain measured by VAS significantly decreased (P < 0.0001) from the score 7.89 to 2.1. The scores of WOMAC-pain, WOMAC-stiffness, and WOMAC-function subscales decreased significantly (P < 0.0001) from 15.9 to 4.4, 3.5 to 0.9, and 49.5 to 17.6, respectively. The WOMAC total score decreased from 68.9 to 22.9 (P < 0.0001).

Conclusions

Ozone is a safe medical treatment that can improve significantly pain relief, stiffness, and function in patients with knee osteoarthritis. The study shows a good level of evidence as well as a good grade of recommendation that allows us to consider Ozone as a conservative therapeutic option in the treatment of osteoarthritis of the knee.

Background

The study was conducted to: 1) demonstrate the effectiveness of a treatment protocol with Ozone therapy in pain, function, and quality of life in patients with knee osteoarthritis; and 2) apply Ozone as a conservative treatment option with a demonstrable level of scientific evidence.

Methods

This prospective quasi-experimental before-after study was conducted on 119 patients with knee osteoarthritis, having Kellgren-Lawrence grade 2 or more, who were referred to hospital of Santa Cristina’s University, from January 2012 to April 2016. The protocol consisted of an intra-articular infiltration of a medical mixture of Oxygen-Ozone (95% - 5%) 20mL, at a 20ug / mL concentration, during a total number of 4 sessions (once per week). Pain and quality of life were measured by visual analogical scale (VAS) and Western Ontarion and Mc Master Universities Index for osteoarthritis (WOMAC) at the beginning and end of the treatment.

Results

The mean age of participants was 66.29 years. The sample was composed of 70.5% Women (n = 84) and 29.5% men (n = 35). The severity of OA according to Kellgren-Lawrence scale was 2.94°. Post-puncture erythema was 8.4% (n = 10). Pain measured by VAS significantly decreased (P < 0.0001) from the score 7.89 to 2.1. The scores of WOMAC-pain, WOMAC-stiffness, and WOMAC-function subscales decreased significantly (P < 0.0001) from 15.9 to 4.4, 3.5 to 0.9, and 49.5 to 17.6, respectively. The WOMAC total score decreased from 68.9 to 22.9 (P < 0.0001).

Knee;Pain;Osteoarthritis;Ozone Therapy;Quality of Life Knee;Pain;Osteoarthritis;Ozone Therapy;Quality of Life http://www.jrehabilhealth.com/index.php?page=article&article_id=41821 Marcos Edgar Fernández Cuadros Marcos Edgar Fernández Cuadros Hospital Universitario Santa Cristina, Madrid, Spain; Fundación Hospital General Santísima Trinidad, Salamanca, Spain; Hospital Universitario Santa Cristina, Madrid, Spain. Tel: +34-620314558 Hospital Universitario Santa Cristina, Madrid, Spain; Fundación Hospital General Santísima Trinidad, Salamanca, Spain; Hospital Universitario Santa Cristina, Madrid, Spain. Tel: +34-620314558 Olga Susana Pérez Moro Olga Susana Pérez Moro Hospital Universitario Santa Cristina, Madrid, Spain Hospital Universitario Santa Cristina, Madrid, Spain María Jesús Albaladejo Florin María Jesús Albaladejo Florin Hospital Universitario Santa Cristina, Madrid, Spain Hospital Universitario Santa Cristina, Madrid, Spain José Antonio Mirón Canelo José Antonio Mirón Canelo Departamento de Salud Pública y Medicina Preventiva, Universidad de Salamanca, Spain Departamento de Salud Pública y Medicina Preventiva, Universidad de Salamanca, Spain