Middle East Journal of Rehabilitation and Health

Published by: Kowsar

Somatic Mutation in Immunoglobulin Gene Variable Region in Patients With Chronic Lymphoid Leukemia and Its Influence on Disease Prognosis

Sanambar Sadighi 1 , Issa Jahanzad 2 , Mohammad Ali Mohagheghi 3 , Mahdieh Shokrollahi Barough 4 , 5 , Mohammad Hojjat-Farsangi 6 , 8 , Kazem Zendehdel 7 and Parviz Kokhaei 4 , 6 , *
Authors Information
1 Hematologist and Medical Oncologist, Cancer Research Center, Tehran University of Medical Sciences, Tehran, IR Iran
2 Pathologist, Pathology Department, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, IR Iran
3 Surgeon, Cancer Research Center, Tehran University of Medical Sciences, Tehran, IR Iran
4 Cancer Research Center, Department of Immunology, Semnan University of Medical Sciences, Semnan, IR Iran
5 Student’s Research Committee, Semnan University of Medical Sciences, Semnan, IR Iran
6 Department of Oncology-Pathology, Immune and Gene Therapy Lab, Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institute, Stockholm, Sweden
7 Cancer Research Center of Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, IR Iran
8 Department of Immunology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, IR Iran
Article information
  • Middle East Journal of Rehabilitation and Health: April 01, 2016, 3 (2); e35848
  • Published Online: March 13, 2016
  • Article Type: Research Article
  • Received: December 27, 2015
  • Revised: February 7, 2016
  • Accepted: February 8, 2016
  • DOI: 10.17795/mejrh-35848

To Cite: Sadighi S, Jahanzad I, Mohagheghi M A, Shokrollahi Barough M, Hojjat-Farsangi M, et al. Somatic Mutation in Immunoglobulin Gene Variable Region in Patients With Chronic Lymphoid Leukemia and Its Influence on Disease Prognosis, Middle East J Rehabil Health Stud. 2016 ; 3(2):e35848. doi: 10.17795/mejrh-35848.

Copyright © 2016, Semnan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Kokhaei P, Rezvany MR, Virving L, Choudhury A, Rabbani H, Osterborg A, et al. Dendritic cells loaded with apoptotic tumour cells induce a stronger T-cell response than dendritic cell-tumour hybrids in B-CLL. Leukemia. 2003; 17(5): 894-9[DOI][PubMed]
  • 2. Herishanu Y, Polliack A. Chronic lymphocytic leukemia: a review of some new aspects of the biology, factors influencing prognosis and therapeutic options. Transfus Apher Sci. 2005; 32(1): 85-97[DOI][PubMed]
  • 3. Tobin G, Thunberg U, Laurell A, Karlsson K, Aleskog A, Willander K, et al. Patients with chronic lymphocytic leukemia with mutated VH genes presenting with Binet stage B or C form a subgroup with a poor outcome. Haematologica. 2005; 90(4): 465-9[PubMed]
  • 4. Adami J, Gridley G, Nyren O, Dosemeci M, Linet M, Glimelius B, et al. Sunlight and non-Hodgkin's lymphoma: a population-based cohort study in Sweden. Int J Cancer. 1999; 80(5): 641-5[PubMed]
  • 5. Diehl LF, Karnell LH, Menck HR. The American College of Surgeons Commission on Cancer and the American Cancer Society. The National Cancer Data Base report on age, gender, treatment, and outcomes of patients with chronic lymphocytic leukemia. Cancer. 1999; 86(12): 2684-92[PubMed]
  • 6. Gaidano G, Foa R, Dalla-Favera R. Molecular pathogenesis of chronic lymphocytic leukemia. J Clin Invest. 2012; 122(10): 3432-8[DOI][PubMed]
  • 7. Matutes E, Owusu-Ankomah K, Morilla R, Garcia Marco J, Houlihan A, Que TH, et al. The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia. 1994; 8(10): 1640-5[PubMed]
  • 8. Goldin LR, Pfeiffer RM, Li X, Hemminki K. Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish Family-Cancer Database. Blood. 2004; 104(6): 1850-4[DOI][PubMed]
  • 9. Hodgson K, Ferrer G, Montserrat E, Moreno C. Chronic lymphocytic leukemia and autoimmunity: a systematic review. Haematologica. 2011; 96(5): 752-61[DOI][PubMed]
  • 10. FMC-7 Expression Identifies Phenotypically Atypical Chronic Lymphocytic Leukemia with Distinct Clinical and Molecular Genetic Features. Georgia World Congress Center.
  • 11. Alfarano A, Indraccolo S, Circosta P, Minuzzo S, Vallario A, Zamarchi R, et al. An alternatively spliced form of CD79b gene may account for altered B-cell receptor expression in B-chronic lymphocytic leukemia. Blood. 1999; 93(7): 2327-35[PubMed]
  • 12. Shanafelt TD, Kay NE. Comprehensive management of the CLL patient: a holistic approach. Hematology Am Soc Hematol Educ Program. 2007; : 324-31[DOI][PubMed]
  • 13. Mozaheb Z, Hasanzadeh NazarAbadi MH, Aghaee MA. Chronic lymphocytic leukemia and prognostic factors. Asian Pac J Cancer Prev. 2012; 13(7): 3009-13[PubMed]
  • 14. Stilgenbauer S, Bullinger L, Lichter P, Dohner H, German CLL Study Group (GCLLSG) . Genetics of chronic lymphocytic leukemia: genomic aberrations and V(H) gene mutation status in pathogenesis and clinical course. Leukemia. 2002; 16(6): 993-1007[DOI][PubMed]
  • 15. Rodriguez-Vicente AE, Diaz MG, Hernandez-Rivas JM. Chronic lymphocytic leukemia: a clinical and molecular heterogenous disease. Cancer Genet. 2013; 206(3): 49-62[DOI][PubMed]
  • 16. Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999; 94(6): 1848-54[PubMed]
  • 17. Damle RN, Wasil T, Fais F, Ghiotto F, Valetto A, Allen SL, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 1999; 94(6): 1840-7[PubMed]
  • 18. Bilous N, Abramenko I, Kryachok I, Bazyka D, Chumak A, Bebeshko V. Significance of VH genes mutation status for prognosis of CLL patients. Exp Oncol. 2005; 27(4): 325-9[PubMed]
  • 19. Messmer BT, Albesiano E, Messmer D, Chiorazzi N. The pattern and distribution of immunoglobulin VH gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process. Blood. 2004; 103(9): 3490-5[DOI][PubMed]
  • 20. Pak F, Mwakigonja AR, Kokhaei P, Hosseinzadeh N, Pyakurel P, Kaaya E, et al. Kaposi's sarcoma herpesvirus load in biopsies of cutaneous and oral Kaposi's sarcoma lesions. Eur J Cancer. 2007; 43(12): 1877-82[DOI][PubMed]
  • 21. Hojjat-Farsangi M, Jeddi-Tehrani M, Razavi SM, Sharifian RA, Mellstedt H, Shokri F, et al. Immunoglobulin heavy chain variable region gene usage and mutational status of the leukemic B cells in Iranian patients with chronic lymphocytic leukemia. Cancer Sci. 2009; 100(12): 2346-53[DOI][PubMed]
  • 22. Chapman CJ, Wright D, Feizi HP, Davis Z, Stevenson FK. V(H) gene analysis of Burkitt's lymphoma in children from north-western Iran. Br J Haematol. 1998; 103(4): 1116-23[PubMed]
  • 23. Farsangi MH, Jeddi-Tehrani M, Sharifian RA, Razavi SM, Khoshnoodi J, Rabbani H, et al. Analysis of the immunoglobulin heavy chain variable region gene expression in Iranian patients with chronic lymphocytic leukemia. Leuk Lymphoma. 2007; 48(1): 109-16[DOI][PubMed]
  • 24. Shokri F, Mageed RA, Richardson P, Jefferis R. Modulation and high frequency expression of autoantibody-associated cross-reactive idiotypes linked to the VHI subgroup in CD5-expressing B lymphocytes from patients with chronic lymphocytic leukaemia (B-CLL). Scand J Immunol. 1993; 37(6): 673-9[PubMed]
  • 25. Gharagozloo S, Sharifian RA, Mageed RA, Shokri F. Analysis of the expressed immunoglobulin variable region heavy chain gene products in paraproteins from Iranian patients with multiple myeloma. Pathol Oncol Res. 2000; 6(3): 185-90[PubMed]
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