Middle East Journal of Rehabilitation and Health

Published by: Kowsar

Enhancing Hippocampal Neuronal Numbers in Morphine-Dependent Rats by Voluntary Exercise Through a Brain-Derived Neurotrophic Factor-Mediated Mechanism

Ali Rashidy-Pour 1 , Yaghoub Fathollahi 2 , Hossein Miladi-Gorji 1 , * and Manouchehr Safari 3
Authors Information
1 Research Center and Department of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, IR Iran
2 Department of Physiology, School of Medical Sciences, Tarbiat Modares University, Tehran, IR Iran
3 Department of Anatomy, School of Medicine, Semnan University of Medical Sciences, Semnan, IR Iran
Article information
  • Middle East Journal of Rehabilitation and Health: January 01, 2015, 2 (1); e25589
  • Published Online: January 24, 2015
  • Article Type: Research Article
  • Received: November 25, 2014
  • Revised: December 29, 2014
  • Accepted: February 1, 2015
  • DOI: 10.17795/mejrh-25589

To Cite: Rashidy-Pour A, Fathollahi Y, Miladi-Gorji H, Safari M. Enhancing Hippocampal Neuronal Numbers in Morphine-Dependent Rats by Voluntary Exercise Through a Brain-Derived Neurotrophic Factor-Mediated Mechanism, Middle East J Rehabil Health Stud. 2015 ; 2(1):e25589. doi: 10.17795/mejrh-25589.

Copyright © 2015, Semnan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Eisch AJ, Nestler EJ. To be or not to be: adult neurogenesis and psychiatry. Clin Neurosci Res. 2002; 2(1-2): 93-108[DOI]
  • 2. Nestler EJ. Molecular basis of long-term plasticity underlying addiction. Nat Rev Neurosci. 2001; 2(2): 119-28[DOI][PubMed]
  • 3. Vorel SR, Liu X, Hayes RJ, Spector JA, Gardner EL. Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science. 2001; 292(5519): 1175-8[DOI][PubMed]
  • 4. Eisch AJ, Barrot M, Schad CA, Self DW, Nestler EJ. Opiates inhibit neurogenesis in the adult rat hippocampus. Proc Natl Acad Sci U S A. 2000; 97(13): 7579-84[DOI][PubMed]
  • 5. Eisch AJ, Mandyam CD. Drug dependence and addiction, II: Adult neurogenesis and drug abuse. Am J Psychiatry. 2004; 161(3): 426[PubMed]
  • 6. Nishijima T, Llorens-Martin M, Tejeda GS, Inoue K, Yamamura Y, Soya H, et al. Cessation of voluntary wheel running increases anxiety-like behavior and impairs adult hippocampal neurogenesis in mice. Behav Brain Res. 2013; 245: 34-41[DOI][PubMed]
  • 7. van Praag H, Kempermann G, Gage FH. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci. 1999; 2(3): 266-70[DOI][PubMed]
  • 8. van Praag H, Shubert T, Zhao C, Gage FH. Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci. 2005; 25(38): 8680-5[DOI][PubMed]
  • 9. van Praag H. Neurogenesis and exercise: past and future directions. Neuromolecular Med. 2008; 10(2): 128-40[DOI][PubMed]
  • 10. Stranahan AM, Zhou Y, Martin B, Maudsley S. Pharmacomimetics of exercise: novel approaches for hippocampally-targeted neuroprotective agents. Curr Med Chem. 2009; 16(35): 4668-78[PubMed]
  • 11. Eisenstein SA, Holmes PV. Chronic and voluntary exercise enhances learning of conditioned place preference to morphine in rats. Pharmacol Biochem Behav. 2007; 86(4): 607-15[DOI][PubMed]
  • 12. Farmer J, Zhao X, van Praag H, Wodtke K, Gage FH, Christie BR. Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. Neuroscience. 2004; 124(1): 71-9[DOI][PubMed]
  • 13. Nestler EJ. Common molecular and cellular substrates of addiction and memory. Neurobiol Learn Mem. 2002; 78(3): 637-47[PubMed]
  • 14. O'Callaghan RM, Ohle R, Kelly AM. The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial- and non-spatial learning. Behav Brain Res. 2007; 176(2): 362-6[DOI][PubMed]
  • 15. Miladi-Gorji H, Rashidy-Pour A, Fathollahi Y, Akhavan MM, Semnanian S, Safari M. Voluntary exercise ameliorates cognitive deficits in morphine dependent rats: the role of hippocampal brain-derived neurotrophic factor. Neurobiol Learn Mem. 2011; 96(3): 479-91[DOI][PubMed]
  • 16. Miladi-Gorji H, Rashidy-Pour A, Fathollahi Y. Anxiety profile in morphine-dependent and withdrawn rats: effect of voluntary exercise. Physiol Behav. 2012; 105(2): 195-202[DOI][PubMed]
  • 17. Miladi-Gorji H, Rashidy-Pour A, Fathollahi Y, Semnanian S, Jadidi M. Effects of voluntary exercise on hippocampal long-term potentiation in morphine-dependent rats. Neuroscience. 2014; 256: 83-90[DOI][PubMed]
  • 18. Vaynman S, Ying Z, Gomez-Pinilla F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci. 2004; 20(10): 2580-90[DOI][PubMed]
  • 19. Ying Z, Roy RR, Zhong H, Zdunowski S, Edgerton VR, Gomez-Pinilla F. BDNF-exercise interactions in the recovery of symmetrical stepping after a cervical hemisection in rats. Neuroscience. 2008; 155(4): 1070-8[DOI][PubMed]
  • 20. Vanoye-Carlo A, Morales T, Ramos E, Mendoza-Rodriguez A, Cerbon M. Neuroprotective effects of lactation against kainic acid treatment in the dorsal hippocampus of the rat. Horm Behav. 2008; 53(1): 112-23[DOI][PubMed]
  • 21. Akhavan MM, Emami-Abarghoie M, Safari M, Sadighi-Moghaddam B, Vafaei AA, Bandegi AR, et al. Serotonergic and noradrenergic lesions suppress the enhancing effect of maternal exercise during pregnancy on learning and memory in rat pups. Neuroscience. 2008; 151(4): 1173-83[DOI][PubMed]
  • 22. Wu CW, Chang YT, Yu L, Chen HI, Jen CJ, Wu SY, et al. Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged mice. J Appl Physiol (1985). 2008; 105(5): 1585-94[DOI][PubMed]
  • 23. Uysal N, Tugyan K, Kayatekin BM, Acikgoz O, Bagriyanik HA, Gonenc S, et al. The effects of regular aerobic exercise in adolescent period on hippocampal neuron density, apoptosis and spatial memory. Neurosci Lett. 2005; 383(3): 241-5[DOI][PubMed]
  • 24. Vaynman S, Ying Z, Gomez-Pinilla F. Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity. Neuroscience. 2003; 122(3): 647-57[PubMed]
  • 25. Oliff HS, Berchtold NC, Isackson P, Cotman CW. Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus. Brain Res Mol Brain Res. 1998; 61(1-2): 147-53[PubMed]
  • 26. Cheng CY, Hong CJ, Yu YW, Chen TJ, Wu HC, Tsai SJ. Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males. Brain Res Mol Brain Res. 2005; 140(1-2): 86-90[DOI][PubMed]
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