Middle East Journal of Rehabilitation and Health

Published by: Kowsar

Effect of Vitamin D on Hippocampus Brain-Derived Neurotrophic Factor Level in Chronic Mild Stress Model of Depression in Rats

Zahra Yousefian 1 , Ali Khaleghian 2 , Homan Parsaei 3 , Abbas Ali Vafaei 1 , Ali Rashidy-Pour 1 and Katayoun Sedaghat 1 , *
Authors Information
1 Research Center of Physiology, Semnan University of Medical Sciences, Semnan, IR Iran
2 Department of Biochemistry, Semnan University of Medical Sciences, Semnan, IR Iran
3 Department of Anatomy, Semnan University of Medical Sciences, Semnan, IR Iran
Article information
  • Middle East Journal of Rehabilitation and Health: April 2018, 5 (2); e63901
  • Published Online: April 21, 2018
  • Article Type: Research Article
  • Received: November 9, 2017
  • Revised: March 12, 2018
  • Accepted: March 14, 2018
  • DOI: 10.5812/mejrh.63901

To Cite: Yousefian Z, Khaleghian A, Parsaei H, Vafaei A A, Rashidy-Pour A, et al. Effect of Vitamin D on Hippocampus Brain-Derived Neurotrophic Factor Level in Chronic Mild Stress Model of Depression in Rats, Middle East J Rehabil Health Stud. 2018 ; 5(2):e63901. doi: 10.5812/mejrh.63901.

Copyright © 2018, Middle East Journal of Rehabilitation and Health Studies. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Materials and Methods
3. Results
4. Discussion
5. Conclusion
  • 1. Aydemir O, Deveci A, Taneli F. The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: a preliminary study. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(2):261-5. doi: 10.1016/j.pnpbp.2004.11.009. [PubMed: 15694233].
  • 2. Langub MC, Herman JP, Malluche HH, Koszewski NJ. Evidence of functional vitamin D receptors in rat hippocampus. Neurosci. 2001;104(1):49-56.
  • 3. Han H, Cui M, You X, Chen M, Piao X, Jin G. A role of 1,25(OH)2D3 supplementation in rats with nonalcoholic steatohepatitis induced by choline-deficient diet. Nutr Metab Cardiovasc Dis. 2015;25(6):556-61. doi: 10.1016/j.numecd.2015.02.011. [PubMed: 25843661].
  • 4. First M, Gil-Ad I, Taler M, Tarasenko I, Novak N, Weizman A. The effects of fluoxetine treatment in a chronic mild stress rat model on depression-related behavior, brain neurotrophins and ERK expression. J Mol Neurosci. 2011;45(2):246-55. doi: 10.1007/s12031-011-9515-5. [PubMed: 21479508].
  • 5. Aguilera M, Arias B, Wichers M, Barrantes-Vidal N, Moya J, Villa H, et al. Early adversity and 5-HTT/BDNF genes: new evidence of gene-environment interactions on depressive symptoms in a general population. Psychol Med. 2009;39(9):1425-32. doi: 10.1017/S0033291709005248. [PubMed: 19215635].
  • 6. Cui X, Pelekanos M, Liu PY, Burne TH, McGrath JJ, Eyles DW. The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain. Neuroscience. 2013;236:77-87. doi: 10.1016/j.neuroscience.2013.01.035. [PubMed: 23352937].
  • 7. Willner P, Towell A, Sampson D, Sophokleous S, Muscat R. Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacol (Berl). 1987;93(3):358-64.
  • 8. Ducottet C, Griebel G, Belzung C. Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2003;27(4):625-31.
  • 9. Grippo AJ, Beltz TG, Johnson AK. Behavioral and cardiovascular changes in the chronic mild stress model of depression. Physiol Behav. 2003;78(4-5):703-10.
  • 10. Gregus A, Wintink AJ, Davis AC, Kalynchuk LE. Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats. Behav Brain Res. 2005;156(1):105-14. doi: 10.1016/j.bbr.2004.05.013. [PubMed: 15474655].
  • 11. Kajta M, Makarewicz D, Zieminska E, Jantas D, Domin H, Lason W, et al. Neuroprotection by co-treatment and post-treating with calcitriol following the ischemic and excitotoxic insult in vivo and in vitro. Neurochem Int. 2009;55(5):265-74. doi: 10.1016/j.neuint.2009.03.010. [PubMed: 19576513].
  • 12. Kalueff AV, Eremin KO, Tuohimaa P. Mechanisms of neuroprotective action of vitamin D(3). Biochemistry (Mosc). 2004;69(7):738-41.

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments