Middle East Journal of Rehabilitation and Health

Published by: Kowsar

Evaluation of a New Method for Biological Activity Analysis of Recombinant Human Parathyroid Hormone-Related Protein

Davood Nasrabadi 1 , 2 , 3 , Siamak Rezaeiani 4 , Ali Sayadmanesh 4 , Mohammad Reza Gharaati 4 , Mohamadreza Baghaban Eslaminejad 2 , * and Aliakbar Shabani 1 , **
Authors Information
1 Medical Biotechnology Department, Semnan University of Medical Sciences, Semnan, Iran
2 Department of Stem Cell and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
3 Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran
4 Department of Molecular Systems Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
Corresponding Authors:
Article information
  • Middle East Journal of Rehabilitation and Health: April 2018, 5 (2); e65828
  • Published Online: April 16, 2018
  • Article Type: Research Article
  • Received: January 2, 2018
  • Revised: February 3, 2018
  • Accepted: February 17, 2018
  • DOI: 10.5812/mejrh.65828

To Cite: Nasrabadi D, Rezaeiani S, Sayadmanesh A, Gharaati M R, Baghaban Eslaminejad M, et al. Evaluation of a New Method for Biological Activity Analysis of Recombinant Human Parathyroid Hormone-Related Protein, Middle East J Rehabil Health Stud. 2018 ; 5(2):e65828. doi: 10.5812/mejrh.65828.

Abstract
Copyright © 2018, Middle East Journal of Rehabilitation and Health Studies. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnote
References
  • 1. Orloff JJ, Reddy D, de Papp AE, Yang KH, Soifer NE, Stewart AF. Parathyroid hormone-related protein as a prohormone: posttranslational processing and receptor interactions. Endocr Rev. 1994;15(1):40-60. doi: 10.1210/edrv-15-1-40. [PubMed: 8156938].
  • 2. Juppner H, Abou-Samra AB, Freeman M, Kong XF, Schipani E, Richards J, et al. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science. 1991;254(5034):1024-6. doi: 10.1126/science.1658941. [PubMed: 1658941].
  • 3. Stewart AF, Horst R, Deftos LJ, Cadman EC, Lang R, Broadus AE. Biochemical evaluation of patients with cancer-associated hypercalcemia: evidence for humoral and nonhumoral groups. N Engl J Med. 1980;303(24):1377-83. doi: 10.1056/NEJM198012113032401. [PubMed: 6253785].
  • 4. Moseley JM, Kubota M, Diefenbach-Jagger H, Wettenhall RE, Kemp BE, Suva LJ, et al. Parathyroid hormone-related protein purified from a human lung cancer cell line. Proc Natl Acad Sci U S A. 1987;84(14):5048-52. doi: 10.1073/pnas.84.14.5048. [PubMed: 2885845].
  • 5. Mueller MB, Fischer M, Zellner J, Berner A, Dienstknecht T, Kujat R, et al. Effect of parathyroid hormone-related protein in an in vitro hypertrophy model for mesenchymal stem cell chondrogenesis. Int Orthop. 2013;37(5):945-51. doi: 10.1007/s00264-013-1800-1. [PubMed: 23371427].
  • 6. Kim YJ, Kim HJ, Im GI. PTHrP promotes chondrogenesis and suppresses hypertrophy from both bone marrow-derived and adipose tissue-derived MSCs. Biochem Biophys Res Commun. 2008;373(1):104-8. doi: 10.1016/j.bbrc.2008.05.183. [PubMed: 18554504].
  • 7. Lee JM, Im GI. PTHrP isoforms have differing effect on chondrogenic differentiation and hypertrophy of mesenchymal stem cells. Biochem Biophys Res Commun. 2012;421(4):819-24. doi: 10.1016/j.bbrc.2012.04.096. [PubMed: 22554518].
  • 8. Madeddu L, Legros N, Devleeschouwer N, Bosman C, Piccart MJ, LeClercq G. Estrogen receptor status and estradiol sensitivity of MCF-7 cells in exponential growth phase. Eur J Cancer Clin Oncol. 1988;24(3):385-90. doi: 10.1016/S0277-5379(98)90007-4. [PubMed: 3383942].
  • 9. Falzon M, Du P. Enhanced growth of MCF-7 breast cancer cells overexpressing parathyroid hormone-related peptide. Endocrinology. 2000;141(5):1882-92. doi: 10.1210/endo.141.5.7470. [PubMed: 10803599].
  • 10. Birch MA, Carron JA, Scott M, Fraser WD, Gallagher JA. Parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor expression and mitogenic responses in human breast cancer cell lines. Br J Cancer. 1995;72(1):90-5. doi: 10.1038/bjc.1995.282. [PubMed: 7599071].
  • 11. Torricelli C, Fortino V, Capurro E, Sacchi G, Ponzo P, Pacini A, et al. Role of PTHrp and PTHrp-engaged pathways in MCF-7 cells migration/invasion. Matrix Biol. 2006;25(2):104-11. doi: 10.1016/j.matbio.2005.09.006. [PubMed: 16455237].
  • 12. Solchaga LA, Penick KJ, Welter JF. Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells: tips and tricks. Methods Mol Biol. 2011;698:253-78. doi: 10.1007/978-1-60761-999-4_20. [PubMed: 21431525].
  • 13. Maioli E, Fortino V. PTHrP on MCF-7 breast cancer cells: a growth factor or an antimitogenic peptide? Br J Cancer. 2004;90(6):1293-4. author reply 1295. doi: 10.1038/sj.bjc.6601689. [PubMed: 15026815].
  • 14. Hoey RP, Sanderson C, Iddon J, Brady G, Bundred NJ, Anderson NG. The parathyroid hormone-related protein receptor is expressed in breast cancer bone metastases and promotes autocrine proliferation in breast carcinoma cells. Br J Cancer. 2003;88(4):567-73. doi: 10.1038/sj.bjc.6600757. [PubMed: 12592371].
  • 15. Natarajan K, Berk BC. Crosstalk coregulation mechanisms of G protein-coupled receptors and receptor tyrosine kinases. Methods Mol Biol. 2006;332:51-77. doi: 10.1385/1-59745-048-0:51. [PubMed: 16878685].
  • 16. Bringhurst FR, Juppner H, Guo J, Urena P, Potts JJ, Kronenberg HM, et al. Cloned, stably expressed parathyroid hormone (PTH)/PTH-related peptide receptors activate multiple messenger signals and biological responses in LLC-PK1 kidney cells. Endocrinology. 1993;132(5):2090-8. doi: 10.1210/endo.132.5.8386606. [PubMed: 8386606].
  • 17. Zhang Y, Kumagai K, Saito T. Effect of parathyroid hormone on early chondrogenic differentiation from mesenchymal stem cells. J Orthop Surg Res. 2014;9:68. doi: 10.1186/s13018-014-0068-5. [PubMed: 25079095].
  • 18. Mueller MB, Fischer M, Zellner J, Berner A, Dienstknecht T, Prantl L, et al. Hypertrophy in mesenchymal stem cell chondrogenesis: effect of TGF-beta isoforms and chondrogenic conditioning. Cells Tissues Organs. 2010;192(3):158-66. doi: 10.1159/000313399. [PubMed: 20407224].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments