Middle East Journal of Rehabilitation and Health

Published by: Kowsar

BMI1 as a Potential Target of miR-330-3p in Colorectal Cancer

Mohammad Hasan Soheilifar 1 , Abdolvahab Moshtaghian 2 , Razieh Amini 1 , Masoud Asefi 1 , Parviz Basiri 1 and Massoud Saidijam 1 , *
Authors Information
1 Research Center for Molecular Medicine and Genetics, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran
2 Deputy of Research and Technology, Semnan University of Medical Sciences, Semnan, Iran
Article information
  • Middle East Journal of Rehabilitation and Health: April 2018, 5 (2); e66075
  • Published Online: April 21, 2018
  • Article Type: Research Article
  • Received: January 20, 2018
  • Revised: February 21, 2018
  • Accepted: March 12, 2018
  • DOI: 10.5812/mejrh.66075

To Cite: Soheilifar M H, Moshtaghian A, Amini R, Asefi M, Basiri P, et al. BMI1 as a Potential Target of miR-330-3p in Colorectal Cancer, Middle East J Rehabil Health Stud. 2018 ; 5(2):e66075. doi: 10.5812/mejrh.66075.

Copyright © 2018, Middle East Journal of Rehabilitation and Health Studies. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 2005;433(7027):769-73. doi: 10.1038/nature03315. [PubMed: 15685193].
  • 2. He D, Miao H, Xu Y, Xiong L, Wang Y, Xiang H, et al. MiR-371-5p facilitates pancreatic cancer cell proliferation and decreases patient survival. PLoS One. 2014;9(11). e112930. doi: 10.1371/journal.pone.0112930. [PubMed: 25411783].
  • 3. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116(2):281-97. doi: 10.1016/S0092-8674(04)00045-5. [PubMed: 14744438].
  • 4. Carthew RW, Sontheimer EJ. Origins and Mechanisms of miRNAs and siRNAs. Cell. 2009;136(4):642-55. doi: 10.1016/j.cell.2009.01.035. [PubMed: 19239886].
  • 5. Maadi H, Moshtaghian A, Taha MF, Mowla SJ, Kazeroonian A, Haass NK, et al. Multimodal tumor suppression by miR-302 cluster in melanoma and colon cancer. Int J Biochem Cell Biol. 2016;81(Pt A):121-32. doi: 10.1016/j.biocel.2016.11.004. [PubMed: 27840154].
  • 6. Anderson EC, Hessman C, Levin TG, Monroe MM, Wong MH. The role of colorectal cancer stem cells in metastatic disease and therapeutic response. Cancers (Basel). 2011;3(1):319-39. doi: 10.3390/cancers3010319. [PubMed: 21318087].
  • 7. Wicha MS. Targeting self-renewal, an Achilles' heel of cancer stem cells. Nat Med. 2014;20(1):14-5. doi: 10.1038/nm.3434. [PubMed: 24398956].
  • 8. O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 2007;445(7123):106-10. doi: 10.1038/nature05372. [PubMed: 17122772].
  • 9. Espersen ML, Olsen J, Linnemann D, Hogdall E, Troelsen JT. Clinical implications of intestinal stem cell markers in colorectal cancer. Clin Colorectal Cancer. 2015;14(2):63-71. doi: 10.1016/j.clcc.2014.12.004. [PubMed: 25657049].
  • 10. Bommi PV, Dimri M, Sahasrabuddhe AA, Khandekar J, Dimri GP. The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors. Cell Cycle. 2010;9(13):2663-73. doi: 10.4161/cc.9.13.12147. [PubMed: 20543557].
  • 11. Rajasekhar VK, Begemann M. Concise review: roles of polycomb group proteins in development and disease: a stem cell perspective. Stem Cells. 2007;25(10):2498-510. doi: 10.1634/stemcells.2006-0608. [PubMed: 17600113].
  • 12. Wang MC, Li CL, Cui J, Jiao M, Wu T, Jing LI, et al. BMI-1, a promising therapeutic target for human cancer. Oncol Lett. 2015;10(2):583-8. doi: 10.3892/ol.2015.3361. [PubMed: 26622537].
  • 13. Jones MF, Hara T, Francis P, Li XL, Bilke S, Zhu Y, et al. The CDX1-microRNA-215 axis regulates colorectal cancer stem cell differentiation. Proc Natl Acad Sci U S A. 2015;112(13):E1550-8. doi: 10.1073/pnas.1503370112. [PubMed: 25775580].
  • 14. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120(1):15-20. doi: 10.1016/j.cell.2004.12.035. [PubMed: 15652477].
  • 15. Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2009;19(1):92-105. doi: 10.1101/gr.082701.108. [PubMed: 18955434].
  • 16. Maragkakis M, Alexiou P, Papadopoulos GL, Reczko M, Dalamagas T, Giannopoulos G, et al. Accurate microRNA target prediction correlates with protein repression levels. BMC Bioinformatics. 2009;10:295. doi: 10.1186/1471-2105-10-295. [PubMed: 19765283].
  • 17. Wang X, El Naqa IM. Prediction of both conserved and nonconserved microRNA targets in animals. Bioinformatics. 2008;24(3):325-32. doi: 10.1093/bioinformatics/btm595. [PubMed: 18048393].
  • 18. Vejnar CE, Blum M, Zdobnov EM. miRmap web: Comprehensive microRNA target prediction online. Nucleic Acids Res. 2013;41(Web Server issue):W165-8. doi: 10.1093/nar/gkt430. [PubMed: 23716633].
  • 19. Betel D, Koppal A, Agius P, Sander C, Leslie C. Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biol. 2010;11(8):R90. doi: 10.1186/gb-2010-11-8-r90. [PubMed: 20799968].
  • 20. Hsu JB, Chiu CM, Hsu SD, Huang WY, Chien CH, Lee TY, et al. miRTar: an integrated system for identifying miRNA-target interactions in human. BMC Bioinformatics. 2011;12:300. doi: 10.1186/1471-2105-12-300. [PubMed: 21791068].
  • 21. Ye W, Lv Q, Wong CK, Hu S, Fu C, Hua Z, et al. The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation. PLoS One. 2008;3(3). e1719. doi: 10.1371/journal.pone.0001719. [PubMed: 18320040].
  • 22. Soheilifar MH, Javeri A, Amini H, Taha MF. Generation of Dopamine-Secreting Cells from Human Adipose Tissue-Derived Stem Cells In Vitro. Rejuvenation Res. 2018. doi: 10.1089/rej.2017.1994. [PubMed: 29207913].
  • 23. Siddique HR, Saleem M. Role of BMI1, a stem cell factor, in cancer recurrence and chemoresistance: preclinical and clinical evidences. Stem Cells. 2012;30(3):372-8. doi: 10.1002/stem.1035. [PubMed: 22252887].
  • 24. Pardal R, Molofsky AV, He S, Morrison SJ. Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors. Cold Spring Harb Symp Quant Biol. 2005;70:177-85. doi: 10.1101/sqb.2005.70.057. [PubMed: 16869752].
  • 25. Wang H, Wang L, Erdjument-Bromage H, Vidal M, Tempst P, Jones RS, et al. Role of histone H2A ubiquitination in Polycomb silencing. Nature. 2004;431(7010):873-8. doi: 10.1038/nature02985. [PubMed: 15386022].
  • 26. Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, et al. The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev. 2007;21(5):525-30. doi: 10.1101/gad.415507. [PubMed: 17344414].
  • 27. Du J, Li Y, Li J, Zheng J. Polycomb group protein Bmi1 expression in colon cancers predicts the survival. Med Oncol. 2010;27(4):1273-6. doi: 10.1007/s12032-009-9373-y. [PubMed: 19957112].
  • 28. Yu T, Chen X, Zhang W, Colon D, Shi J, Napier D, et al. Regulation of the potential marker for intestinal cells, Bmi1, by beta-catenin and the zinc finger protein KLF4: implications for colon cancer. J Biol Chem. 2012;287(6):3760-8. doi: 10.1074/jbc.M111.316349. [PubMed: 22170051].
  • 29. Kreso A, van Galen P, Pedley NM, Lima-Fernandes E, Frelin C, Davis T, et al. Self-renewal as a therapeutic target in human colorectal cancer. Nat Med. 2014;20(1):29-36. doi: 10.1038/nm.3418. [PubMed: 24292392].
  • 30. Wang H, Jiang Y, Peng H, Chen Y, Zhu P, Huang Y. Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors. Adv Drug Deliv Rev. 2015;81:142-60. doi: 10.1016/j.addr.2014.10.031. [PubMed: 25450259].
  • 31. Wang C, Guan S, Chen X, Liu B, Liu F, Han L, et al. Clinical potential of miR-3651 as a novel prognostic biomarker for esophageal squamous cell cancer. Biochem Biophys Res Commun. 2015;465(1):30-4. doi: 10.1016/j.bbrc.2015.07.109. [PubMed: 26210449].
  • 32. Ren LL, Chen HY, Hong J, Fang JY. A master microRNA miR-508-3p modulates the mesenchymal subtype of colorectal cancer by targeting ZEB1/BMI1/SALL4 network. Clin Gastroenterol Hepatol. 2015;13(7). e81. doi: 10.1016/j.cgh.2015.04.058.
  • 33. He X, Dong Y, Wu CW, Zhao Z, Ng SS, Chan FK, et al. MicroRNA-218 inhibits cell cycle progression and promotes apoptosis in colon cancer by downregulating BMI1 polycomb ring finger oncogene. Mol Med. 2013;18:1491-8. doi: 10.2119/molmed.2012.00304. [PubMed: 23255074].
  • 34. Hodzic J, Giovannetti E, Diosdado B, Adema AD, Peters GJ. Regulation of deoxycytidine kinase expression and sensitivity to gemcitabine by micro-RNA 330 and promoter methylation in cancer cells. Nucleosides Nucleotides Nucleic Acids. 2011;30(12):1214-22. doi: 10.1080/15257770.2011.629271. [PubMed: 22132977].
  • 35. Li Y, Zhu X, Xu W, Wang D, Yan J. miR-330 regulates the proliferation of colorectal cancer cells by targeting Cdc42. Biochem Biophys Res Commun. 2013;431(3):560-5. doi: 10.1016/j.bbrc.2013.01.016. [PubMed: 23337504].
  • 36. Guan A, Wang H, Li X, Xie H, Wang R, Zhu Y, et al. MiR-330-3p inhibits gastric cancer progression through targeting MSI1. Am J Transl Res. 2016;8(11):4802-11. [PubMed: 27904681].
  • 37. Pasto A, Serafin V, Pilotto G, Lago C, Bellio C, Trusolino L, et al. NOTCH3 signaling regulates MUSASHI-1 expression in metastatic colorectal cancer cells. Cancer Res. 2014;74(7):2106-18. doi: 10.1158/0008-5472.CAN-13-2022. [PubMed: 24525742].
  • 38. Pun JC, Chan JY, Chun BK, Ng KW, Tsui SY, Wan TM, et al. Plasma Bmi1 mRNA as a potential prognostic biomarker for distant metastasis in colorectal cancer patients. Mol Clin Oncol. 2014;2(5):817-20. doi: 10.3892/mco.2014.321. [PubMed: 25054051].
  • 39. Zeng W, Tu Y, Zhu Y, Wang Z, Li C, Lao L, et al. Predictive power of circulating miRNAs in detecting colorectal cancer. Tumour Biol. 2015;36(4):2559-67. doi: 10.1007/s13277-014-2872-2. [PubMed: 25527153].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments